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Evaluation of Media Treatment Options


Adventitious agent control of media is crucial for preventing contaminations.  The CAACB has three sub-projects on methods of treating media to remove or inactivate potential viruses.

  • The first sub-project centers around the ‘Harmonization of HTST Inactivation of MVM’. It was initiated because three published sets of data drew disparate conclusions about the efficacy of HTST inactivation of MVM. The project tackled whether the reported inactivation results diverged due to differences in experimental design or other causative factors. Additional data and analysis will allow for a consensus on the efficacy of HTST inactivation of MVM.
  • The second sub-project is on the ‘Economic Analysis of Media Treatment Technologies’. It surveyed technologies capable of inactivating or removing viral agents in cell-culture media. The development and implementation of these technologies has an impact on cost of goods. The CAACB reviewed cost estimates for barrier technologies, such as HTST treatment, UV-C, and nanofiltration, and designed a tool to aid companies in estimating the expense of implementing such technologies.
  • Lastly, the CAACB is conducting a sub-project on the ‘Evaluation of Media Treatment Effectiveness’. Prior to this work, a database of virus inactivation or removal from media for HTST, UV-C and nanofiltration technologies did not exist. The CAACB addressed this absence by assembling and analyzing existing viral inactivation and removal data for media treatment from literature and confidential data from member companies. This data has been collected into a single source that can be leveraged by CAACB members.


  • Members Only White Paper and Cost Modeling Tool on ‘Economic Analysis of Media Treatment Technologies’
  • Members Only White Paper on ‘A Survey of Industry and Literature Data on HTST, UVC, and Nanofiltration for Media Treatment and Their Efficacy for Inactivation of Virus and Microbes’


See all CAACB research