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The Consortium on Adventitious Agent Contamination in Biomanufacturing (CAACB)

The Consortium on Adventitious Agent Contamination in Biomanufacturing (CAACB) is a biopharmaceutical industry consortium with the mission of pooling biomanufacturing expertise in the area of adventitious agent contamination.

 

CAACB GOALS

Provide a safe and collaborative environment for companies to share their experiences, lessons learned and operational approaches to control and mitigate the risk of adventitious agent contamination in biomanufacturing.

Identify best industry practices currently utilized by biomanufacturing companies to control and mitigate the risk of adventitious agent contamination.

Sponsor collaborative research activities and initiatives to promote a better understanding of how to address adventitious agent contamination.

Promote the generation and application of new technologies to detect and identify adventitious agents and to mitigate the risk of contamination.

Publish the results of this work. To accomplish these goals, the CAACB conducts workshops (one- to two-day interactive meetings with presentations, case studies and open discussion) and projects.

 

PROJECTS

Virus Contaminations in Biomanufacturing
The CAACB has confidentially collected and analyzed industry-wide viral contamination data to help guide companies in best practices to mitigate the risks that lead to these events.

Effectiveness of Media Treatment Technologies
The CAACB is collecting and analyzing existing viral inactivation and removal data for media treatment into a single source to aid industry in evaluating these technologies.

Economic Analysis of Media Treatment Technologies
The CAACB has developed a White Paper and costing tool for viral barrier technologies to aid companies in estimating the cost of implementing common media treatment technologies.

Risk Assessment and Risk Control of Virus Contaminations
The CAACB has compiled a Virus Contamination Risk Assessment and Risk Control “handbook” to help companies assess the risk of high impact, low frequency virus contamination events.

Facility Segregation for Viral Safety
CAACB members have developed a consensus definition of common facility segregation terms, such as “functionally closed”, and identified facility segregation approaches to ensure adequate viral safety.