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CBI Publications

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Biomanufacturing@MIT-CBI
Publications

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D. Guttieres, A.J. Sinskey, S.L. Springs
Modeling Framework to Evaluate Vaccine Strategies against the COVID-19 Pandemic
Systems, 2021, 9(1), 4

P.W. Barone, F.J. Keumurian, M.E. Wiebe, J. Wolfrum, J.C. Leung, A.J. Sinskey, S.L. Springs
The Impact of SARS-CoV-2 on Biomanufacturing Operations.
BioPharm International, Volume 33, Issue 8, August 1, 2020

P.W. Barone, M.E. Wiebe, J.C. Leung, et al. 
Viral contamination in biologic manufacture and implications for emerging therapies.
Nat Biotechnol 38, 563–572, April 27, 2020

D. Gutierres, S.R. Stewart, J. Wolfrum, S.L. Springs,
Cyberbiosecurity in Advanced Manufacturing Models.
Frontiers in Bioengineering and Biotechnology, September, 2019

S.R Stewart, P.W. Barone, A. Bellisario, C.L. Cooney, P.A Sharp, A.J. Sinskey, S. Natesan, S.L. Springs
Leveraging Industry-Academia Collaborations in Adaptive Biomedical Innovation.
Clin. Pharm. Ther. 100 (6), 647-653. PMID: 27617845, 2016

US Chapter of the United Nations Educational, Scientific and Cultural Organization (UNESCO) 2015 Science Report: “The United States of America.” S.R. Stewart and S.L.Springs.
UNESCO Science Report 2015: Towards 2030.
UNESCO Publishing. November 10, 2015.

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NEWDIGS
Publications

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J. Barlow, R. Teagarden, M. Trusheim
Precision Financing of Durable, Potentially Curative Therapies
Pharmaceutical Executive, January, 2019

G. Hirsch, M. Trusheim, E. Cobbs, M. Bala, S. Garner, D. Hartman, K. Isaacs, M. Lumpkin, R. Lim, K. Oye, E. Pezalla, P. Saltonstall, H. Selker
Adaptive Biomedical Innovation: Evolving Our Global System to Sustainably and Safely Bring New Medicines to Patients in Need
Clinical Pharmacology & Therapeutics, 10.1002/cpt.509, 2016

H.G. Eichler, L.G. Baird, R. Barker, et al
From adaptive licensing to adaptive pathways: Delivering a flexible life-span approach to bring new drugs to patients
Clinical Pharmacology & Therapeutics, 10.1002/cpt.59, 2014

M. Papadaki, G. Hirsch
Curing Consortium Fatigue
Science Translational Medicine, 10.1126/scitranslmed.3006903, 2013

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Recent Affiliated Faculty
Publications

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L. Yin, Z. Yang, Y. Wu, V. Denslin, C.C. Yu, C.A. Tee, C.T. Lim, J. Han, E.H. Lee
Label-free separation of mesenchymal stem cell subpopulations with distinct differentiation potencies and paracrine effects.
Biomaterials, vol 240 119881, May, 2020

E. Içten, A.J. Maloney, M.G. Beaver, D.E. Shen, X.Zhu, L.R. Graham, J.A. Robinson, S. Huggins, A. Allian, R. Hart, S.D. Walker, P. Rolandi, and R.D. Braatz
A Virtual Plant for Integrated Continuous Manufacturing of a Carfilzomib Drug Substance Intermediate, Part 1: CDI-Promoted Amide Bond Formation.
Org. Process Res. Dev. 24, 10, 1861–1875, 2020

E. Içten, A.J. Maloney, M.G. Beaver, D.E. Shen, X.Zhu, L.R. Graham, J.A. Robinson, S. Huggins, A. Allian, R. Hart, S.D. Walker, P. Rolandi, and R.D. Braatz
A Virtual Plant for Integrated Continuous Manufacturing of a Carfilzomib Drug Substance Intermediate, Part 2: Enone Synthesis via a Barbier-Type Grignard Process.
Org. Process Res. Dev. 24, 10, 1876–1890, 2020

E. Içten, A.J. Maloney, M.G. Beaver, D.E. Shen, X.Zhu, L.R. Graham, J.A. Robinson, S. Huggins, A. Allian, R. Hart, S.D. Walker, P. Rolandi, and R.D. Braatz
A Virtual Plant for Integrated Continuous Manufacturing of a Carfilzomib Drug Substance Intermediate, Part 3: Manganese-Catalyzed Asymmetric Epoxidation, Crystallization, and Filtration.
Org. Process Res. Dev. 24, 10, 1891–1908, 2020

N. Han, R.J. Ram
Bayesian modeling and computation for analyte quantification in complex mixtures using Raman spectroscopy.
Computational Statistics & Data Analysis, vol 143, 106846, March 2020

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