Biographies

Dr. Stacy Springs is the Executive Director at the MIT Center for Biomedical Innovation (CBI).  The Center integrates the Institute’s technical, scientific, and management expertise to solve complex biopharmaceutical challenges.  CBI leads multi-stakeholder, multidisciplinary research and educational initiatives with real world impact, including MIT’s Biomanufacturing Consortium, (BioMAN), and it’s Consortium on Adventitious Agent Contamination in Biomanufacturing, (CAACB).  Dr. Springs is a principle investigator on several research programs in biologics manufacturing, from application of data analytics and PAT in the continuous production of monoclonal antibodies, viral vectors and vaccines, to development of innovative rapid sterility tests and new approaches to adventitious agent contamination through long read sequencing.  Dr. Springs is part of the leadership of SMART CAMP, an interdisciplinary research group focused on Critical Analytics for Manufacturing Personalized-Medicine at the Singapore-MIT Alliance for Research and Technology (SMART) and serves as the Chair of Landmark Bio’s Science and Technology Committee. 

Dr. Springs’ research interests include biopharmaceutical development and manufacturing, risk management, regulatory and translational science and food safety and food supply chains.  She holds a PhD in Chemistry from the University of Texas at Austin and gained postdoctoral training in protein and biophysical chemistry at Princeton University.

Select Publications

Katsikis, G., Hwang, I.E., Wang, W., Bhat, V.S., McIntosh, N.L., Karim, O.A., Blus, B.J., Sha, S., Agache, V., Wolfrum, J.M., Springs, S.L., Sinskey, A.J., Barone, P.W., Braatz, R.D., Manalis, S.R.
Weighing the DNA content of adeno-associated virus vectors with Zeptogram precision using nanomechanical resonators. 
Nano Letters, 2022, 22, 4, 1511-1517

Huang, J., Cui, L., Meenubharathi, N., Barone, P.W., Wolfrum, J.M., Lee, Y.H., Rice, S.A., Springs, S.L.,
The ratio of nicotinic acid to nicotinamide as a microbial biomarker for assessing cell therapy product sterility.
Molecular Therapy; Methods & Clinical Development, Volume 25, June 2022

Wu, X., Chan, C., Springs, S.L., Lee, Y.H., Lu, T.K., Yu, H., 
A warm-start digital CRISPR/Cas-based method for the quantitative detection of nucleic acids.
Analytica Chimica Acta, Volume 1196, March 2022

Wu, X., Tay, J.K., Goh, C.K., Chan, C., Lee, Y.H., Springs, S.L., Wang, D.Y., Loh, K.S., Lu, T.K., Yu, H.
A Rapid DIgital Crispr Approach (RADICA) for the detection and absolute quantification of nucleic acids.
Frontiers in Biological Detection: From Nanosensors to Systems XIV, Volume PC11979, March 2022

Hong, M.S., Lu, A.E., Maloney, A.J., Ou, R.W., Wolfrum, J.M., Springs, S.L., Sinskey, A.J., Braatz, R.D. 
Applying PAT to the continuous digital biomanufacturing of monoclonal antibodies.
Pharma Focus Asia, Volume 44, 42-46, 2022

Chen, L., Guttieres, D., Koenigsburg, A., Barone, P.W., Sinskey, A.J., Springs, S.L.,
Large-scale cultured meat production: Trends, challenges and promising biomanufacturing technologies.
Biomaterials, Volume 280, January 2022

Sha, S., Maloney, A.J., Katsikis, G., Nguyen, T.N.T., Neufeld, C., Wolfrum, J.,  Barone, P.W., Springs, S.L., Manalis, S.R., Sinskey A.J.,  Braatz, R.D.
Cellular Pathways of recombinant Adeno-Associated Virus Production for Gene Therapy.
Biotechnology Advances, Volume 49, May 2021

Nguyen, T.N.T., Sha, S., Hong, M.S., Maloney, A.J., Barone, P.W., Neufeld, C., Wolfrum, J.M., Springs, S.L., Sinskey, A.J., Braatz, R.D.
Mechanistic model for production of recombinant adeno-associated virus via triple transfection of HEK293 cells.
Molecular Therapy, Methods & Clinical Development, June 2021, Vol. 21, 642-655

D. Guttieres, A.J. Sinskey, S.L. Springs
Modeling Framework to Evaluate Vaccine Strategies against the COVID-19 Pandemic
Systems, 2021, 9(1), 4

P.W. Barone, F.J. Keumurian, M.E. Wiebe, J. Wolfrum, J.C. Leung, A.J. Sinskey, S.L. Springs
The Impact of SARS-CoV-2 on Biomanufacturing Operations.
BioPharm International, Volume 33, Issue 8, August 1, 2020

P.W. Barone, M.E. Wiebe, J.C. Leung, et al. 
Viral contamination in biologic manufacture and implications for emerging therapies.
Nat Biotechnol 38, 563–572, April 27, 2020

D. Gutierres, S.R. Stewart, J. Wolfrum, S.L. Springs,
Cyberbiosecurity in Advanced Manufacturing Models.
Frontiers in Bioengineering and Biotechnology, September, 2019

S.R Stewart, P.W. Barone, A. Bellisario, C.L. Cooney, P.A Sharp, A.J. Sinskey, S. Natesan, S.L. Springs
Leveraging Industry-Academia Collaborations in Adaptive Biomedical Innovation.
Clin. Pharm. Ther. 100 (6), 647-653. PMID: 27617845, 2016

US Chapter of the United Nations Educational, Scientific and Cultural Organization (UNESCO) 2015 Science Report: “The United States of America.” S.R. Stewart and S.L.Springs.
UNESCO Science Report 2015: Towards 2030.
UNESCO Publishing. November 10, 2015.Molecular Therapiy