Biographies

Stacy Springs

Dr. Stacy Springs serves as the Senior Director of Programs at MIT’s Center for Biomedical Innovation and as the Executive Director of Biomanufacturing Initiatives including MIT’s Biomanufacturing Consortium, (BioMAN), its Consortia on Adventitious Agent Contamination in Biomanufacturing, (CAACB), and the BioACCESS initiative.  The objective of BioMAN is to develop knowledge, science, technologies and strategies that advance the global manufacture and delivery of high quality biopharamaceuticals.  The CAACB pools biopharmaceutical manufacturing expertise in the area of adventitious agent contamination to better enable a safe and dependable delivery of life-saving biologics.  BioACCESS seeks to better understand the growing need for and barriers to safe, effective, and affordable health services in low- and middle-income countries, especially biologic therapies for chronic and non-communicable diseases.  In addition, Dr. Springs serves as the Executive Director for the Sloan School’s Food Supply Chain Analytics and Sensing Initiative, (FSAS) as well as participating in the Critical Analytics for Manufacturing Personalized-Medicine (CAMP) program, an interdisciplinary research group at the Singapore-MIT Alliance for Research and Technology (SMART).

She holds a PhD in Chemistry from the University of Texas at Austin and gained postdoctoral training in protein and biophysical chemistry at Princeton University.

Select Publications

Huang, J., Cui, L., Meenubharathi, N., Barone, P.W., Wolfrum, J.M., Lee, Y.H., Rice, S.A., Springs, S.L.,
The ratio of nicotinic acid to nicotinamide as a microbial biomarker for assessing cell therapy product sterility.
Molecular Therapy; Methods & Clinical Development, Volume 25, June 2022

Wu, X., Chan, C., Springs, S.L., Lee, Y.H., Lu, T.K., Yu, H., 
A warm-start digital CRISPR/Cas-based method for the quantitative detection of nucleic acids.
Analytica Chimica Acta, Volume 1196, March 2022

Hong, M.S., Lu, A.E., Maloney, A.J., Ou, R.W., Wolfrum, J.M., Springs, S.L., Sinskey, A.J., Braatz, R.D. 
Applying PAT to the continuous digital biomanufacturing of monoclonal antibodies.
Pharma Focus Asia, Volume 44, 42-46, 2022

Chen, L., Guttieres, D., Koenigsburg, A., Barone, P.W., Sinskey, A.J., Springs, S.L.,
Large-scale cultured meat production: Trends, challenges and promising biomanufacturing technologies.
Biomaterials, Volume 280, January 2022

Sha, S., Maloney, A.J., Katsikis, G., Nguyen, T.N.T., Neufeld, C., Wolfrum, J.,  Barone, P.W., Springs, S.L., Manalis, S.R., Sinskey A.J.,  Braatz, R.D.
Cellular Pathways of recombinant Adeno-Associated Virus Production for Gene Therapy.
Biotechnology Advances, Volume 49, May 2021

D. Guttieres, A.J. Sinskey, S.L. Springs
Modeling Framework to Evaluate Vaccine Strategies against the COVID-19 Pandemic
Systems, 2021, 9(1), 4

P.W. Barone, F.J. Keumurian, M.E. Wiebe, J. Wolfrum, J.C. Leung, A.J. Sinskey, S.L. Springs
The Impact of SARS-CoV-2 on Biomanufacturing Operations.
BioPharm International, Volume 33, Issue 8, August 1, 2020

P.W. Barone, M.E. Wiebe, J.C. Leung, et al. 
Viral contamination in biologic manufacture and implications for emerging therapies.
Nat Biotechnol 38, 563–572, April 27, 2020

D. Gutierres, S.R. Stewart, J. Wolfrum, S.L. Springs,
Cyberbiosecurity in Advanced Manufacturing Models.
Frontiers in Bioengineering and Biotechnology, September, 2019

S.R Stewart, P.W. Barone, A. Bellisario, C.L. Cooney, P.A Sharp, A.J. Sinskey, S. Natesan, S.L. Springs
Leveraging Industry-Academia Collaborations in Adaptive Biomedical Innovation.
Clin. Pharm. Ther. 100 (6), 647-653. PMID: 27617845, 2016

US Chapter of the United Nations Educational, Scientific and Cultural Organization (UNESCO) 2015 Science Report: “The United States of America.” S.R. Stewart and S.L.Springs.
UNESCO Science Report 2015: Towards 2030.
UNESCO Publishing. November 10, 2015.Molecular Therapiy